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Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes

BACKGROUND: Oxygen and glucose metabolism play pivotal roles in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) during ischemia and stroke results in extensive tissue injury and cell death. RESULTS: Using time-resolved ribosome profiling, we assess gene expr...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Andreev, Dmitry E, O’Connor, Patrick BF, Zhdanov, Alexander V, Dmitriev, Ruslan I, Shatsky, Ivan N, Papkovsky, Dmitri B, Baranov, Pavel V
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419486/
https://ncbi.nlm.nih.gov/pubmed/25943107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0651-z
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