Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma through miR-210 delivery

Intercellular communication between tumor cells within the hypoxic microenvironment promote aggressiveness and poor patient prognoses for reasons that remain unclear. Here we show that hypoxic Ewing’s sarcoma (EWS) cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS c...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kling, Matthew J., Chaturvedi, Nagendra K., Kesherwani, Varun, Coulter, Don W., McGuire, Timothy R., Sharp, J. Graham, Joshi, Shantaram S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546758/
https://ncbi.nlm.nih.gov/pubmed/33088424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27702
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