Improved therapy for neuroblastoma using a combination approach: superior efficacy with vismodegib and topotecan

Aberrant activation/expression of pathways/molecules including NF-kB, mTOR, hedgehog and polo-like-kinase-1 (PLK1) are correlated with poor-prognosis neuroblastoma. Therefore, to identify a most efficacious treatment for neuroblastoma, we investigated the efficacy of NF-kB/mTOR dual-inhibitor 13-197...

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Vydáno v:Oncotarget
Hlavní autoři: Chaturvedi, Nagendra K., McGuire, Timothy R., Coulter, Don W., Shukla, Ashima, McIntyre, Erin M., Sharp, John Graham, Joshi, Shantaram S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924781/
https://ncbi.nlm.nih.gov/pubmed/26934655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7714
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