Suppression of STAT3 NH(2)-Terminal Domain Chemosensitizes Medulloblastoma Cells by Activation of Protein Inhibitor of Activated STAT3 via de-repression by MicroRNA-21.

Medulloblastoma (MB) is a malignant pediatric brain tumor with poor prognosis. Signal transducers and activators of transcription-3 (STAT3) is constitutively activated in MB where it functions as an oncoprotein, mediating cancer progression and metastasis. Here, we have delineated the functional rol...

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Udgivet i:Mol Carcinog
Main Authors: Ray, Sutapa, Coulter, Don W, Gray, Shawn D, Sughroue, Jason A, Roychoudhury, Shrabasti, McIntyre, Erin M, Chaturvedi, Nagendra K, Bhakat, Kishor K, Joshi, Shantaram S, McGuire, Timothy R, Sharp, John G
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132241/
https://ncbi.nlm.nih.gov/pubmed/29280516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22778
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