Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery

Patients with relapsed or refractory acute myeloid leukemia (AML) have a dismal prognosis and limited treatment options. Chimeric antigen receptor (CAR) T cells have achieved unprecedented clinical responses in patients with B cell leukemias and lymphomas and could prove highly efficacious in AML. H...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Sommer, Cesar, Cheng, Hsin-Yuan, Nguyen, Duy, Dettling, Danielle, Yeung, Yik Andy, Sutton, Janette, Hamze, Moustafa, Valton, Julien, Smith, Julianne, Djuretic, Ivana, Chaparro-Riggers, Javier, Sasu, Barbra J.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544976/
https://ncbi.nlm.nih.gov/pubmed/32592688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.06.022
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