Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

Por Chaparro-Riggers, Javier, Liang, Hong, DeVay, Rachel M., Bai, Lanfang, Sutton, Janette E., Chen, Wei, Geng, Tao, Lindquist, Kevin, Casas, Meritxell Galindo, Boustany, Leila M., Brown, Colleen L., Chabot, Jeffrey, Gomes, Bruce, Garzone, Pamela, Rossi, Andrea, Strop, Pavel, Shelton, Dave, Pons, Jaume, Rajpal, Arvind
Publicado em 2012

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy

Por Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A., Hasa-Moreno, Adela, Farias, Santiago E., Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Sutton, Janette, Bolton, Gary, Zhou, Dahui, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L., Pons, Jaume, Rajpal, Arvind
Publicado no PLoS One (2015)