Hedgehog signaling enables repair of ribosomal DNA double-strand breaks

Ribosomal DNA (rDNA) consists of highly repeated sequences that are prone to incurring damage. Delays or failure of rDNA double-strand break (DSB) repair are deleterious, and can lead to rDNA transcriptional arrest, chromosomal translocations, genomic losses, and cell death. Here, we show that the z...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Lama-Sherpa, Tshering D, Lin, Victor T G, Metge, Brandon J, Weeks, Shannon E, Chen, Dongquan, Samant, Rajeev S, Shevde, Lalita A
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544215/
https://ncbi.nlm.nih.gov/pubmed/32894284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa733
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