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An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks

Radiation, alkylating agents, and platinum-based chemotherapy treatments eliminate cancer cells through the induction of excessive DNA damage. The resultant DNA damage challenges the cancer cell’s DNA repair capacity. Among the different types of DNA damage induced in cells, double-strand breaks (DS...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Lama-Sherpa, Tshering D., Shevde, Lalita A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002210/
https://ncbi.nlm.nih.gov/pubmed/31676722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0665
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