Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer

Host responses to tumor cells include tumor suppressing or promoting mechanisms. We sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the mammary tumor immune portfolio. We hypothesized that Hh signaling mediates a crosstalk between breast cancer cells and macroph...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Hanna, Ann, Metge, Brandon J., Bailey, Sarah K., Chen, Dongquan, Chandrashekar, Darshan S., Varambally, Sooryanarayana, Samant, Rajeev S., Shevde, Lalita A.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350695/
https://ncbi.nlm.nih.gov/pubmed/30723576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1548241
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