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Lineage reversion drives WNT independence in intestinal cancer
The WNT pathway is a fundamental regulator of intestinal homeostasis and hyperactivation of WNT signaling is the major oncogenic driver in colorectal cancer (CRC). To date, there are no described mechanisms that bypass WNT dependence in intestinal tumors. Here, we show that while WNT suppression blo...
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| Publicado no: | Cancer Discov |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7541594/ https://ncbi.nlm.nih.gov/pubmed/32546576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1536 |
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