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Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Anti-Tumor Efficacy of PD-1 Blockade

Despite unprecedented advances in the treatment of cancer through the use of immune checkpoint blockade, responses are not universal and alternative strategies are needed to enhance responses to ICB. We have shown previously that a novel polyamine blocking therapy (PBT), consisting of co-treatment w...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Alexander, Eric T., Mariner, Kelsey, Donnelly, Julia, Phanstiel, Otto, Gilmour, Susan K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541445/
https://ncbi.nlm.nih.gov/pubmed/32747421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-1116
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