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Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment

Correcting T cell immunosuppression may unleash powerful antitumor responses, however, knowledge about the mechanisms and modifiers that may be targeted to improve therapy remains incomplete. Here we report that polyamine elevation in cancer, a common metabolic aberration in aggressive lesions, cont...

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Библиографические подробности
Главные авторы: Hayes, Candace S., Shicora, Allyson C., Keough, Martin P., Snook, Adam E., Burns, Mark R., Gilmour, Susan K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101915/
https://ncbi.nlm.nih.gov/pubmed/24778323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0120-T
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