Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

JCPyV polyomavirus, a member of the human virome, causes progressive multifocal leukoencephalopathy (PML), an oft-fatal demyelinating brain disease in individuals receiving immunomodulatory therapies. Mutations in the major viral capsid protein, VP1, are common in JCPyV from PML patients (JCPyV-PML)...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lauver, Matthew D, Goetschius, Daniel J, Netherby-Winslow, Colleen S, Ayers, Katelyn N, Jin, Ge, Haas, Daniel G, Frost, Elizabeth L, Cho, Sung Hyun, Bator, Carol M, Bywaters, Stephanie M, Christensen, Neil D, Hafenstein, Susan L, Lukacher, Aron E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541085/
https://ncbi.nlm.nih.gov/pubmed/32940605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61056
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