Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells

ABT‐263 (Navitoclax) is a BH3‐mimetic drugs targeting anti‐apoptotic B‐cell lymphoma‐2 (BCL‐2) family proteins, including BCL‐2, BCL‐xL, and BCL‐w, thereby inducing apoptosis. In small‐cell lung cancer (SCLC) cells, the response to ABT‐263 is associated with the expression of myeloid cell leukemia‐1...

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Dades bibliogràfiques
Publicat a:Cancer Sci
Autors principals: Ohgino, Keiko, Terai, Hideki, Yasuda, Hiroyuki, Nukaga, Shigenari, Hamamoto, Junko, Tani, Tetsuo, Kuroda, Aoi, Arai, Daisuke, Ishioka, Kota, Masuzawa, Keita, Ikemura, Shinnosuke, Kawada, Ichiro, Naoki, Katsuhiko, Fukunaga, Koichi, Soejima, Kenzo
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Drug Discovery and Delivery
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541018/
https://ncbi.nlm.nih.gov/pubmed/32687646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14569
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