Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

We identified transmembrane protease, serine 4 (TMPRSS4) as a putative, druggable target by screening surgically resected samples from 90 Japanese non-small-cell lung cancer (NSCLC) patients using cDNA microarray. TMPRSS4 has two druggable domains and was upregulated in 94.5% of the lung cancer spec...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Sci
Päätekijät: Hamamoto, Junko, Soejima, Kenzo, Naoki, Katsuhiko, Yasuda, Hiroyuki, Hayashi, Yuichiro, Yoda, Satoshi, Nakayama, Sohei, Satomi, Ryosuke, Terai, Hideki, Ikemura, Shinnosuke, Sato, Takashi, Arai, Daisuke, Ishioka, Kota, Ohgino, Keiko, Betsuyaku, Tomoko
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BlackWell Publishing Ltd 2015
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317784/
https://ncbi.nlm.nih.gov/pubmed/25414083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12569
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