Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

We identified transmembrane protease, serine 4 (TMPRSS4) as a putative, druggable target by screening surgically resected samples from 90 Japanese non-small-cell lung cancer (NSCLC) patients using cDNA microarray. TMPRSS4 has two druggable domains and was upregulated in 94.5% of the lung cancer spec...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hamamoto, Junko, Soejima, Kenzo, Naoki, Katsuhiko, Yasuda, Hiroyuki, Hayashi, Yuichiro, Yoda, Satoshi, Nakayama, Sohei, Satomi, Ryosuke, Terai, Hideki, Ikemura, Shinnosuke, Sato, Takashi, Arai, Daisuke, Ishioka, Kota, Ohgino, Keiko, Betsuyaku, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317784/
https://ncbi.nlm.nih.gov/pubmed/25414083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12569
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