Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells

ABT‐263 (Navitoclax) is a BH3‐mimetic drugs targeting anti‐apoptotic B‐cell lymphoma‐2 (BCL‐2) family proteins, including BCL‐2, BCL‐xL, and BCL‐w, thereby inducing apoptosis. In small‐cell lung cancer (SCLC) cells, the response to ABT‐263 is associated with the expression of myeloid cell leukemia‐1...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Autores principales: Ohgino, Keiko, Terai, Hideki, Yasuda, Hiroyuki, Nukaga, Shigenari, Hamamoto, Junko, Tani, Tetsuo, Kuroda, Aoi, Arai, Daisuke, Ishioka, Kota, Masuzawa, Keita, Ikemura, Shinnosuke, Kawada, Ichiro, Naoki, Katsuhiko, Fukunaga, Koichi, Soejima, Kenzo
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Drug Discovery and Delivery
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541018/
https://ncbi.nlm.nih.gov/pubmed/32687646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14569
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