Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells

ABT‐263 (Navitoclax) is a BH3‐mimetic drugs targeting anti‐apoptotic B‐cell lymphoma‐2 (BCL‐2) family proteins, including BCL‐2, BCL‐xL, and BCL‐w, thereby inducing apoptosis. In small‐cell lung cancer (SCLC) cells, the response to ABT‐263 is associated with the expression of myeloid cell leukemia‐1...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Ohgino, Keiko, Terai, Hideki, Yasuda, Hiroyuki, Nukaga, Shigenari, Hamamoto, Junko, Tani, Tetsuo, Kuroda, Aoi, Arai, Daisuke, Ishioka, Kota, Masuzawa, Keita, Ikemura, Shinnosuke, Kawada, Ichiro, Naoki, Katsuhiko, Fukunaga, Koichi, Soejima, Kenzo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Drug Discovery and Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541018/
https://ncbi.nlm.nih.gov/pubmed/32687646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14569
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