Isothiourea‐Catalyzed Acylative Kinetic Resolution of Tertiary α‐Hydroxy Esters

A highly enantioselective isothiourea‐catalyzed acylative kinetic resolution (KR) of acyclic tertiary alcohols has been developed. Selectivity factors of up to 200 were achieved for the KR of tertiary alcohols bearing an adjacent ester substituent, with both reaction conversion and enantioselectivit...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Qu, Shen, Smith, Samuel M., Laina‐Martín, Víctor, Neyyappadath, Rifahath M., Greenhalgh, Mark D., Smith, Andrew D.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540711/
https://ncbi.nlm.nih.gov/pubmed/32491267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004354
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