Isothiourea‐Catalyzed Acylative Kinetic Resolution of Tertiary α‐Hydroxy Esters

A highly enantioselective isothiourea‐catalyzed acylative kinetic resolution (KR) of acyclic tertiary alcohols has been developed. Selectivity factors of up to 200 were achieved for the KR of tertiary alcohols bearing an adjacent ester substituent, with both reaction conversion and enantioselectivit...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Qu, Shen, Smith, Samuel M., Laina‐Martín, Víctor, Neyyappadath, Rifahath M., Greenhalgh, Mark D., Smith, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540711/
https://ncbi.nlm.nih.gov/pubmed/32491267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004354
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