E35 ablates acute leukemia stem and progenitor cells in vitro and in vivo

Leukemia stem cells (LSCs) have critical functions in acute leukemia (AL) pathogenesis, participating in its initiation and relapse. Thus, identifying new molecules to eradicate LSCs represents a high priority for AL management. This work identified E35, a novel Emodin derivative, which strongly inh...

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Publicat a:J Cell Physiol
Autors principals: Chen, Yingyu, Zheng, Jing, Gan, Donghui, Chen, Yanxin, Zhang, Na, Chen, Yuwen, Lin, Zhenxing, Wang, Wenfeng, Chen, Haijun, Lin, Donghong, Hu, Jianda
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540425/
https://ncbi.nlm.nih.gov/pubmed/31960417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.29457
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