Doxorubicin/Nucleophosmin Binding Protein-Conjugated Nanoparticle Enhances Anti-leukemia Activity in Acute Lymphoblastic Leukemia Cells in vitro and in vivo

Acute lymphoblastic leukemia (ALL) is an aggressive malignancy. Adults with ALL have more than 50% relapse rates. We have previously validated that overexpression of nucleophosmin (NPM) is involved in the multidrug resistance (MDR) development during ALL; and a synthetically engineered recombinant N...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Gan, Donghui, Chen, Yuwen, Wu, Zhengjun, Luo, Liping, Yirga, Shimuye Kalayu, Zhang, Na, Ye, Fu, Chen, Haijun, Hu, Jianda, Chen, Yingyu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193937/
https://ncbi.nlm.nih.gov/pubmed/34122059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.607755
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