PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification

The establishment of protective humoral immunity is dependent on the ability of mature B cells to undergo antibody gene diversification while adjusting to the physiological stressors induced by activation with the antigen. Mature B cells diversify their antibody genes by class switch recombination (...

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Publicado no:J Exp Med
Main Authors: Delgado-Benito, Verónica, Berruezo-Llacuna, Maria, Altwasser, Robert, Winkler, Wiebke, Sundaravinayagam, Devakumar, Balasubramanian, Sandhya, Caganova, Marieta, Graf, Robin, Rahjouei, Ali, Henke, Marie-Thérèse, Driesner, Madlen, Keller, Lisa, Prigione, Alessandro, Janz, Martin, Akalin, Altuna, Di Virgilio, Michela
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537392/
https://ncbi.nlm.nih.gov/pubmed/32609329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200137
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