Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...

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Auteurs principaux: Sandhya Balasubramanian, Matteo Andreani, Júlia Goncalves Andrade, Tannishtha Saha, Devakumar Sundaravinayagam, Javier Garzón, Wenzhu Zhang, Oliver Popp, Shin-ichiro Hiraga, Ali Rahjouei, Daniel B Rosen, Philipp Mertins, Brian T Chait, Anne D Donaldson, Michela Di Virgilio
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications Ltd 2022-04-01
Collection:eLife
Sujets:
RIF1
SQ motifs
intrinsically disordered region
DSB resection inhibition
DNA replication fork protection
Accès en ligne:https://elifesciences.org/articles/75047
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