Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients

B-cell chronic lymphocytic leukemia (CLL) results from accumulation of leukemic cells that are subject to iterative re-activation cycles and clonal expansion in lymphoid tissues. The effects of the well-tolerated alkaloid Berberine (BRB), used for treating metabolic disorders, were studied on ex-viv...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ravera, Silvia, Ghiotto, Fabio, Tenca, Claudya, Gugiatti, Elena, Santamaria, Sara, Ledda, Bernardetta, Ibatici, Adalberto, Cutrona, Giovanna, Mazzarello, Andrea N., Bagnara, Davide, Cardillo, Martina, Zarcone, Daniela, Darzynkiewicz, Zbigniew, Ciccone, Ermanno, Fais, Franco, Bruno, Silvia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536443/
https://ncbi.nlm.nih.gov/pubmed/33020573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73594-z
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