Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues

Lysine lactoylation is a recently described protein post-translational modification (PTM). However, the biochemical pathways responsible for this acylation remain unclear. Two metabolite-dependent mechanisms have been proposed: enzymatic histone lysine lactoylation derived from lactoyl-coenzyme A (l...

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Enregistré dans:
Détails bibliographiques
Publié dans:Open Biol
Auteurs principaux: Varner, Erika L., Trefely, Sophie, Bartee, David, von Krusenstiern, Eliana, Izzo, Luke, Bekeova, Carmen, O'Connor, Roddy S., Seifert, Erin L., Wellen, Kathryn E., Meier, Jordan L., Snyder, Nathaniel W.
Format: Artigo
Langue:Inglês
Publié: The Royal Society 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536085/
https://ncbi.nlm.nih.gov/pubmed/32961073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.200187
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