Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

Cancer metastasis accounts for the major cause of cancer-related deaths. How disseminated cancer cells cope with hostile microenvironments in secondary site for full-blown metastasis is largely unknown. Here, we show that AMPK (AMP-activated protein kinase), activated in mouse metastasis models, dri...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Cai, Zhen, Li, Chien-Feng, Han, Fei, Liu, Chunfang, Zhang, Anmei, Hsu, Che-Chia, Peng, Danni, Zhang, Xian, Jin, Guoxiang, Rezaeian, Abdol-Hossein, Wang, Guihua, Zhang, Weina, Pan, Bo-Syong, Wang, Chi-Yun, Wang, Yu-Hui, Wu, Shih-Ying, Yang, Shun-Chin, Hsu, Fang-Chi, D’Agostino, Ralph B., Furdui, Christina M., Kucera, Gregory L., Parks, John S., Chilton, Floyd H., Huang, Chih-Yang, Tsai, Fuu-Jen, Pasche, Boris, Watabe, Kounosuke, Lin, Hui-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534735/
https://ncbi.nlm.nih.gov/pubmed/33022274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.09.018
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