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Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance

The century-old embryonal/gametogenesis hypothesis of tumors could link diverse tumors’ malignant features together likely representing the real “stemness” of tumors. However, the genetic evidence to validate abnormal gametogenesis in tumors remains lacking. Here we show that p53 deficiency elicits...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Liu, Chunfang, Cai, Zhen, Jin, Guoxiang, Peng, Danni, Pan, Bo-Syong, Zhang, Xian, Han, Fei, Xu, Xiaohong, Lin, Hui-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167385/
https://ncbi.nlm.nih.gov/pubmed/30302273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0054-x
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