TRAF6 restricts p53 mitochondrial translocation, apoptosis and tumor suppression

Mitochondrial p53 is involved in apoptosis and tumor suppression. However, its regulation is not well studied. Here, we show that TRAF6 E3 ligase is a crucial factor to restrict mitochondrial translocation of p53 and spontaneous apoptosis by promoting K63-linked ubiquitination of p53 at K24 in cytos...

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Publicado no:Mol Cell
Main Authors: Zhang, Xian, Li, Chien-Feng, Zhang, Ling, Wu, Ching-Yuan, Han, Lixia, Jin, Guoxiang, Rezaeian, Abdol Hossein, Han, Fei, Liu, Chunfang, Xu, Chuan, Xu, Xiaohong, Huang, Chih-Yang, Tsai, Fuu-Jen, Tsai, Chang-Hai, Watabe, Kounosuke, Lin, Hui-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541903/
https://ncbi.nlm.nih.gov/pubmed/27818144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.10.002
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