A hypoxia-responsive TRAF6-ATM-H2A.X signalling axis promotes HIF1α activation, tumorigenesis and metastasis

The understanding of how hypoxia stabilizes and activates HIF1α in the nucleus with related oncogenic signals can revolutionize targeted therapy for cancers. Here, we find that histone H2AX displays oncogenic activity by serving as a crucial regulator of HIF1α signalling. H2AX interacts with and pre...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Rezaeian, Abdol-Hossein, Li, Chien-Feng, Wu, Ching-Yuan, Zhang, Xian, Delacerda, Jorge, You, M. James, Han, Fei, Cai, Zhen, Jeong, Yun Seong, Jin, Guoxiang, Phan, Liem, Chou, Ping-Chieh, Lee, Mong-Hong, Hung, Mien-Chie, Sarbassov, Dos, Lin, Hui-Kuan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441459/
https://ncbi.nlm.nih.gov/pubmed/27918549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3445
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