Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment

Duchenne muscular dystrophy is a genetic disorder that shows chronic and progressive damage to skeletal and cardiac muscle leading to premature death. Antiinflammatory corticosteroids targeting the glucocorticoid receptor (GR) are the current standard of care but drive adverse side effects such as d...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Liu, Xu, Wang, Yashuo, Gutierrez, Jennifer S., Damsker, Jesse M., Nagaraju, Kanneboyina, Hoffman, Eric P., Ortlund, Eric A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533876/
https://ncbi.nlm.nih.gov/pubmed/32917814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006890117
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