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Exposure-Response Analysis of Vamorolone (VBP15) in Boys with Duchenne Muscular Dystrophy

Exposure-response (E-R) relationships of vamorolone, a novel dissociative steroidal anti-inflammatory drug, were investigated in clinical trials in boys with Duchenne Muscular Dystrophy (DMD). Variables were clinical outcome measures, Fridericia-corrected QT (QTcF) duration, and pharmacodynamic (PD)...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Li, Xiaonan, Conklin, Laurie S., van den Anker, John, Hoffman, Eric P., Clemens, Paula R., Jusko, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494537/
https://ncbi.nlm.nih.gov/pubmed/32434278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1632
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