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Causal inference in genetic trio studies

We introduce a method to draw causal inferences—inferences immune to all possible confounding—from genetic data that include parents and offspring. Causal conclusions are possible with these data because the natural randomness in meiosis can be viewed as a high-dimensional randomized experiment. We...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Bates, Stephen, Sesia, Matteo, Sabatti, Chiara, Candès, Emmanuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533659/
https://ncbi.nlm.nih.gov/pubmed/32948695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007743117
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