Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice

The tumour suppressor gene, TES, is frequently methylated in many human tumours. Previously, we demonstrated that TES promoter methylation and transcriptional silencing was the most common molecular abnormality detected in childhood acute lymphoblastic leukaemia (ALL). Trp53-mutant mouse models pred...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Weeks, Robert J., Ludgate, Jackie L., Le Mée, Gwenn, Khanal, Rubina, Mehta, Sunali, Williams, Gail, Slatter, Tania L., Braithwaite, Antony W., Morison, Ian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530732/
https://ncbi.nlm.nih.gov/pubmed/33004921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73229-3
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