The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion

The extracellular accumulation of amyloid β (Aβ) fragments of amyloid precursor protein (APP) in brain parenchyma is a pathological hallmark of Alzheimer’s disease (AD). APP can be cleaved into Aβ on late endosomes/multivesicular bodies (MVBs). E3 ubiquitin ligases have been linked to Aβ production,...

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Publicado en:Mol Cell Neurosci
Autores principales: Gireud-Goss, Monica, Reyes, Sahily, Tewari, Ritika, Patrizz, Anthony, Howe, Matthew D., Kofler, Julia, Waxham, M. Neal, McCullough, Louise D., Bean, Andrew J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530133/
https://ncbi.nlm.nih.gov/pubmed/32841720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2020.103542
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