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Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway

Misfolding and aggregation of proteins is strongly linked to several neurodegenerative diseases, but how such species bring about their cytotoxic actions remains poorly understood. Here we used specifically-designed optical reporter probes and live fluorescence imaging in primary hippocampal neurons...

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Bibliografiske detaljer
Udgivet i:Cell Mol Life Sci
Main Authors: Marshall, Karen E., Vadukul, Devkee M., Staras, Kevin, Serpell, Louise C.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658065/
https://ncbi.nlm.nih.gov/pubmed/32025743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03464-4
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