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Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway

Misfolding and aggregation of proteins is strongly linked to several neurodegenerative diseases, but how such species bring about their cytotoxic actions remains poorly understood. Here we used specifically-designed optical reporter probes and live fluorescence imaging in primary hippocampal neurons...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Marshall, Karen E., Vadukul, Devkee M., Staras, Kevin, Serpell, Louise C.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658065/
https://ncbi.nlm.nih.gov/pubmed/32025743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03464-4
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