Orally Efficacious Broad-Spectrum Allosteric Inhibitor of Paramyxovirus Polymerase

Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3, a major cause of acute respiratory infection, we identified GHP-88309, a non-nucleoside inhibitor of viral polymerase activit...

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Pubblicato in:Nat Microbiol
Autori principali: Cox, Robert M, Sourimant, Julien, Toots, Mart, Yoon, Jeong-Joong, Ikegame, Satoshi, Govindarajan, Mugunthan, Watkinson, Ruth E, Thibault, Patricia, Makhsous, Negar, Lin, Michelle J., Marengo, Jose R, Sticher, Zachary, Kolykhalov, Alexander A, Natchus, Michael G, Greninger, Alexander L, Lee, Benhur, Plemper, Richard K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529989/
https://ncbi.nlm.nih.gov/pubmed/32661315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0752-7
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