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Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity

Morbilliviruses, such as measles virus (MeV) and canine distemper virus (CDV), are highly infectious members of the paramyxovirus family. MeV is responsible for major morbidity and mortality in non-vaccinated populations. ERDRP-0519, a pan-morbillivirus small molecule inhibitor for the treatment of...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Cox, Robert M., Sourimant, Julien, Govindarajan, Mugunthan, Natchus, Michael G., Plemper, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935272/
https://ncbi.nlm.nih.gov/pubmed/33621266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009371
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