Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro

AIMS/HYPOTHESIS: Aggregation of the beta cell secretory product human islet amyloid polypeptide (hIAPP) results in islet amyloid deposition, a pathological feature of type 2 diabetes. Amyloid formation is associated with increased levels of islet IL-1β as well as beta cell dysfunction and death, but...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Templin, Andrew T., Mellati, Mahnaz, Meier, Daniel T., Esser, Nathalie, Hogan, Meghan F., Castillo, Joseph J., Akter, Rehana, Raleigh, Daniel P., Zraika, Sakeneh, Hull, Rebecca L., Kahn, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529980/
https://ncbi.nlm.nih.gov/pubmed/32728889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05232-2
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