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Advancing physiological maturation in human iPSC-derived cardiac muscle by gene editing an inducible adult troponin isoform switch

Advancing maturation of stem cell-derived cardiac muscle represents a major barrier to progress in cardiac regenerative medicine. Cardiac muscle maturation involves a myriad of gene, protein and cell-based transitions, spanning across all aspects of cardiac muscle form and function. We focused here...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Wheelwright, Matthew, Mikkila, Jennifer, Bedada, Fikru B., Mandegar, Mohammad A., Thompson, Brian R., Metzger, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529900/
https://ncbi.nlm.nih.gov/pubmed/32497296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3235
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