Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema

Rationale: Endothelial injury may provoke emphysema, but molecular pathways of disease development require further discernment. Emphysematous lungs exhibit decreased expression of HIF-2α (hypoxia-inducible factor-2α)-regulated genes, and tobacco smoke decreases pulmonary HIF-2α concentrations. These...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Pasupneti, Shravani, Tian, Wen, Tu, Allen B., Dahms, Petra, Granucci, Eric, Gandjeva, Aneta, Xiang, Menglan, Butcher, Eugene C., Semenza, Gregg L., Tuder, Rubin M., Jiang, Xinguo, Nicolls, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2020
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528783/
https://ncbi.nlm.nih.gov/pubmed/32515984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.202001-0078OC
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