Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema

Pathologic lymphatic remodeling in lymphedema evolves during periods of tissue inflammation and hypoxia through poorly defined processes. In human and mouse lymphedema, there is a significant increase of hypoxia inducible factor 1 α (HIF-1α), but a reduction of HIF-2α protein expression in lymphatic...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Jiang, Xinguo, Tian, Wen, Granucci, Eric J., Tu, Allen B., Kim, Dongeon, Dahms, Petra, Pasupneti, Shravani, Peng, Gongyong, Kim, Yesl, Lim, Amber H., Espinoza, F. Hernan, Cribb, Matthew, Dixon, J. Brandon, Rockson, Stanley G., Semenza, Gregg L., Nicolls, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524470/
https://ncbi.nlm.nih.gov/pubmed/32673288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136164
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