Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema

Pathologic lymphatic remodeling in lymphedema evolves during periods of tissue inflammation and hypoxia through poorly defined processes. In human and mouse lymphedema, there is a significant increase of hypoxia inducible factor 1 α (HIF-1α), but a reduction of HIF-2α protein expression in lymphatic...

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Publicado en:J Clin Invest
Main Authors: Jiang, Xinguo, Tian, Wen, Granucci, Eric J., Tu, Allen B., Kim, Dongeon, Dahms, Petra, Pasupneti, Shravani, Peng, Gongyong, Kim, Yesl, Lim, Amber H., Espinoza, F. Hernan, Cribb, Matthew, Dixon, J. Brandon, Rockson, Stanley G., Semenza, Gregg L., Nicolls, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524470/
https://ncbi.nlm.nih.gov/pubmed/32673288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136164
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