Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema

Pathologic lymphatic remodeling in lymphedema evolves during periods of tissue inflammation and hypoxia through poorly defined processes. In human and mouse lymphedema, there is a significant increase of hypoxia inducible factor 1 α (HIF-1α), but a reduction of HIF-2α protein expression in lymphatic...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Jiang, Xinguo, Tian, Wen, Granucci, Eric J., Tu, Allen B., Kim, Dongeon, Dahms, Petra, Pasupneti, Shravani, Peng, Gongyong, Kim, Yesl, Lim, Amber H., Espinoza, F. Hernan, Cribb, Matthew, Dixon, J. Brandon, Rockson, Stanley G., Semenza, Gregg L., Nicolls, Mark R.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524470/
https://ncbi.nlm.nih.gov/pubmed/32673288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136164
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