Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema

Pathologic lymphatic remodeling in lymphedema evolves during periods of tissue inflammation and hypoxia through poorly defined processes. In human and mouse lymphedema, there is a significant increase of hypoxia inducible factor 1 α (HIF-1α), but a reduction of HIF-2α protein expression in lymphatic...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Jiang, Xinguo, Tian, Wen, Granucci, Eric J., Tu, Allen B., Kim, Dongeon, Dahms, Petra, Pasupneti, Shravani, Peng, Gongyong, Kim, Yesl, Lim, Amber H., Espinoza, F. Hernan, Cribb, Matthew, Dixon, J. Brandon, Rockson, Stanley G., Semenza, Gregg L., Nicolls, Mark R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2020
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524470/
https://ncbi.nlm.nih.gov/pubmed/32673288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136164
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