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The structure of the MICU1‐MICU2 complex unveils the regulation of the mitochondrial calcium uniporter
The MICU1‐MICU2 heterodimer regulates the mitochondrial calcium uniporter (MCU) and mitochondrial calcium uptake. Herein, we present two crystal structures of the MICU1‐MICU2 heterodimer, in which Ca(2+)‐free and Ca(2+)‐bound EF‐hands are observed in both proteins, revealing both electrostatic and h...
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| Publicado no: | EMBO J |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7527922/ https://ncbi.nlm.nih.gov/pubmed/32790952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104285 |
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