Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf

As a deubiqutinase Otub1 stabilizes and promotes the oncogenic activity of the transcription factor c-Maf in multiple myeloma (MM), a malignancy of plasma cells. In the screen for bioactive inhibitors of the Otub1/c-Maf axis for MM treatment, nanchangmycin (Nam), a polyketide antibiotic, was identif...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Xu, Yujia, Sun, Tong, Zeng, Kun, Xu, Min, Chen, Jinhao, Xu, Xiaofeng, Zhang, Zubin, Cao, Biyin, Tang, Xiaowen, Wu, Depei, Kong, Yan, Zeng, Yuanying, Mao, Xinliang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527563/
https://ncbi.nlm.nih.gov/pubmed/32999280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03017-4
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