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PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates

Cell cycle progression is negatively regulated by the retinoblastoma family of pocket proteins and CDK inhibitors (CKIs). In contrast, CDKs promote progression through multiple phases of the cell cycle. One prominent way by which CDKs promote cell cycle progression is by inactivation of pocket prote...

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Bibliografiske detaljer
Udgivet i:Gene
Main Authors: Kurimchak, Alison, Graña, Xavier
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527233/
https://ncbi.nlm.nih.gov/pubmed/22387205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2012.02.015
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