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PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer

Protein Phosphatase 2A (PP2A) consists of a collection of heterotrimeric serine/threonine phosphatase holoenzymes that play multiple roles in cell signaling via dephosphorylation of numerous substrates of a large family of serine/threonine kinases. PP2A substrate specificity is mediated by B regulat...

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Bibliografiske detaljer
Main Authors: Kurimchak, Alison, Graña, Xavier
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636755/
https://ncbi.nlm.nih.gov/pubmed/23634261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912473479
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