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PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

In their active hypophosphorylated state, members of the retinoblastoma family of pocket proteins negatively regulate cell cycle progression at least in part by repressing expression of E2F-dependent genes. Mitogen-dependent activation of G1 and G1/S Cyclin Dependent Kinases (CDKs) results in coordi...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Kurimchak, Alison, Graña, Xavier
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612414/
https://ncbi.nlm.nih.gov/pubmed/25483052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.985069
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