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Fitness Cost and Compensatory Evolution in Levofloxacin-Resistant Mycobacterium aurum

We isolated spontaneous levofloxacin-resistant strains of Mycobacterium aurum to study the fitness cost and compensatory evolution of fluoroquinolone resistance in mycobacteria. Five of six mutant strains with substantial growth defects showed restored fitness after being serially passaged for 18 gr...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Pi, Rui, Liu, Qingyun, Takiff, Howard E., Gao, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526816/
https://ncbi.nlm.nih.gov/pubmed/32482677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00224-20
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